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European Perspectives


Circulating Tumor Cells Identify Patients with Super-High-Risk Non-Muscle-Invasive Bladder Cancer: Updated Outcome Analysis of a Prospective Single-Center Trial

Chiara Nicolazzo, Gian Maria Busetto, Angela Gradilone, Isabella Sperduti, Francesco del Giudice, Flavia Loreni, Enrico Cortesi, Ettore de Berardinis, Paola Gazzaniga, Cristina Raimondi

The Oncologist first published on April 3, 2019; doi:10.1634/theoncologist.2018-0784


The EMA Review of Mylotarg (Gemtuzumab Ozogamicin) for the Treatment of Acute Myeloid Leukemia

Sahra Ali, Helen-Marie Dunmore, Dominik Karres, Justin L. Hay, Tomas Salmonsson, Christian Gisselbrecht, Sinan B. Sarac, Ole W. Bjerrum, Doris Hovgaard, Yolanda Barbachano, Nithyanandan Nagercoil, Francesco Pignatti

The Oncologist first published on March 21, 2019; doi:10.1634/theoncologist.2019-0025


Prospective Observational Study of Pazopanib in Patients with Advanced Renal Cell Carcinoma (PRINCIPAL Study)

Sanchez, Sergio Vázquez, Narayanan Srihari, Haralabos Kalofonos, Petri Bono, Chaitali Babanrao Pisal, Yulia Hirschberg, Luca Dezzani, Qasim Ahmad, Eric Jonasch, on behalf of the PRINCIPAL Study Group

The Oncologist first published on March 13, 2019; doi:10.1634/theoncologist.2018-0787


From Diagnostic-Therapeutic Pathways to Real-World Data: A Multicenter Prospective Study on Upfront Treatment for EGFR-Positive Non-Small Cell Lung Cancer (MOST Study)

Giulia Pasello, Giovanni Vicario, Fable Zustovich, Francesco Oniga, Stefania Gori, Francesco Rosetti, Andrea Bonetti, Adolfo Favaretto, Silvia Toso, Roberta Redelotti, Antonio Santo, Daniele Bernardi, Petros Giovanis, Cristina Oliani, Lorenzo Calvetti, Carlo Gatti, Giovanni Palazzolo, Zora Baretta, Alberto Bortolami, Laura Bonanno, Marco Basso, Jessica Menis, Donatella Da Corte, Stefano Frega, Valentina Guarneri, PierFranco Conte, on behalf of Veneto Oncology Network

The Oncologist first published on March 7, 2019; doi:10.1634/theoncologist.2018-0712


Clinical Outcomes of Patients with Advanced Cancer and Pre-Existing Autoimmune Diseases Treated with Anti-Programmed Death-1 Immunotherapy: A Real-World Transverse Study

Alessio Cortellini, Sebastiano Buti, Daniele Santini, Fabiana Perrone, Raffaele Giusti, Marcello Tiseo, Melissa Bersanelli, Maria Michiara, Antonino Grassadonia, Davide Brocco, Nicola Tinari, Michele De Tursi, Federica Zoratto, Enzo Veltri, Riccardo Marconcini, Francesco Malorgio, Carlo Garufi, Marco Russano, Cecilia Anesi, Tea Zeppola, Marco Filetti, Paolo Marchetti, Andrea Botticelli, Gian Carlo Antonini Cappellini, Federica De Galitiis, Maria Giuseppa Vitale, Roberto Sabbatini, Sergio Bracarda, Rossana Berardi, Silvia Rinaldi, Marianna Tudini, Rosa Rita Silva, Annagrazia Pireddu, Francesco Atzori, Rita Chiari, Biagio Ricciuti, Daniela Iacono, Maria Rita Migliorino, Antonio Rossi, Giampiero Porzio, Katia Cannita, Valeria Ciciarelli, Maria Concetta Fargnoli, Paolo Antonio Ascierto, Corrado Ficorella

The Oncologist first published on February 22, 2019; doi:10.1634/theoncologist.2018-0618


Postsurgical Approaches in Low-Grade Oligodendroglioma: Is Chemotherapy Alone Still an Option?

Enrico Franceschi, Alicia Tosoni, Dario De Biase, Giuseppe Lamberti, Daniela Danieli, Stefano Pizzolitto, Elena Zunarelli, Michela Visani, Enrico Di Oto, Antonella Mura, Santino Minichillo, Chiara Scafati, Sofia Asioli, Alexandro Paccapelo, Stefania Bartolini, Alba A. Brandes

The Oncologist first published on February 18, 2019; doi:10.1634/theoncologist.2018-0549/p>


Neoadjuvant Management of Early Breast Cancer: A Clinical and Investigational Position Statement

Ramon Colomer, Cristina Saura, Pedro Sánchez-Rovira, Tomás Pascual, Isabel T. Rubio, Octavio Burgués, Lourdes Marcos, César A. Rodríguez, Miguel Martín, Ana Lluch

The Oncologist first published on February 1, 2019; doi:10.1634/theoncologist.2018-0228


T-Cell Lymphopenia in Patients with Advanced Thyroid Carcinoma Is Associated with Poor Prognosis

Katrin Rabold, Paul R. Gielen, Esther D. Kers-Rebel, Mihai G. Netea, Jan W.A. Smit, Gosse J. Adema, Romana T. Netea-Maier

The Oncologist first published on January 3, 2019; doi:10.1634/theoncologist.2018-0422


Impact of Metformin Use and Diabetic Status During Adjuvant Fluoropyrimidine-Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis

Claudio Vernieri, Fabio Galli, Laura Ferrari, Paolo Marchetti, Sara Lonardi, Evaristo Maiello, Rosario V. Iaffaioli, Maria G. Zampino, Alberto Zaniboni, Sabino De Placido, Maria Banzi, Azzurra Damiani, Daris Ferrari, Gerardo Rosati, Roberto F. Labianca, Paolo Bidoli, Giovanni L. Frassineti, Mario Nicolini, Lorenzo Pavesi, Maria C. Tronconi, Angela Buonadonna, Sabrina Ferrario, Giovanni Lo Re, Vincenzo Adamo, Emiliano Tamburini, Mario Clerico, Paolo Giordani, Francesco Leonardi, Sandro Barni, Andrea Ciarlo, Luigi Cavanna, Stefania Gori, Saverio Cinieri, Marina Faedi, Massimo Aglietta, Maria Antista, Katia F. Dotti, Francesca Galli, Maria Di Bartolomeo, on behalf of TOSCA (Three or Six Colon Adjuvant) Investigators

The Oncologist first published on January 3, 2019; doi:10.1634/theoncologist.2018-0442


Nasoethmoidal Intestinal-Type Adenocarcinoma Treated with Cetuximab: Role of Liquid Biopsy and BEAMing in Predicting Response to Anti-Epidermal Growth Factor Receptor Therapy

Santiago Cabezas-Camarero, Virginia de la Orden García, Vanesa García-Barberán, Beatriz Mediero-Valeros, Ahmad Issa Subhi-Issa, Patricia Llovet García, Inmaculada Bando-Polaino, Salomé Merino Menéndez, Pedro Pérez-Segura, Eduardo Díaz-Rubio

The Oncologist first published on January 2, 2019; doi:10.1634/theoncologist.2018-0387


Phase II Study of Dehydroepiandrosterone in Androgen Receptor-Positive Metastatic Breast Cancer

Elisabetta Pietri, Ilaria Massa, Sara Bravaccini, Sara Ravaioli, Maria Maddalena Tumedei, Elisabetta Petracci, Caterina Donati, Alessio Schirone, Federico Piacentini, Lorenzo Gianni, Mario Nicolini, Enrico Campadelli, Alessandra Gennari, Alessandro Saba, Beatrice Campi, Linda Valmorri, Daniele Andreis, Francesco Fabbri, Dino Amadori, Andrea Rocca

The Oncologist first published on December 27, 2018; doi:10.1634/theoncologist.2018-0243


Eribulin Mesylate as Third or Subsequent Line Chemotherapy for Elderly Patients with Locally Recurrent or Metastatic Breast Cancer: A Multicentric Observational Study of GIOGer (Italian Group of Geriatric Oncology)-ERIBE

Silvana Leo, Ermenegildo Arnoldi, Lazzaro Repetto, Zaira Coccorullo, Saverio Cinieri, Palma Fedele, Marina Cazzaniga, Vito Lorusso, Agnese Latorre, Giovanna Campanella, Mariangela Ciccarese, Caterina Accettura, Salvatore Pisconti, Antonio Rinaldi, Cosimo Brunetti, Mimma Raffaele, Luigi Coltelli, Salvatore Spazzapan, Lucia Fratino, Luciana Petrucelli, Laura Biganzoli

The Oncologist first published on November 9, 2018; doi:10.1634/theoncologist.2017-0676


Relevance of Reference Centers in Sarcoma Care and Quality Item Evaluation: Results from the Prospective Registry of the Spanish Group for Research in Sarcoma (GEIS)

Javier Martin-Broto, Nadia Hindi, Josefina Cruz, Javier Martinez-Trufero, Claudia Valverde, Luis M. De Sande, Angeles Sala, Lorena Bellido, Ana De Juan, Jordi Rubió-Casadevall, Roberto Diaz-Beveridge, Ricardo Cubedo, Oscar Tendero, Diego Salinas, Isidro Gracia, Rafael Ramos, Silvia Baguè, Antonio Gutierrez, José Duran-Moreno, Antonio Lopez-Pousa

The Oncologist first published on November 8, 2018; doi:10.1634/theoncologist.2018-0121


Symptom Expression in Patients with Advanced Cancer Admitted to an Acute Supportive/Palliative Care Unit With and Without Delirium

Sebastiano Mercadante, Claudio Adile, Patrizia Ferrera, Andrea Cortegiani, Alessandra Casuccio

The Oncologist first published on October 24, 2018; doi:10.1634/theoncologist.2018-0244


A Randomized Phase II Trial (TAMIGA) Evaluating the Efficacy and Safety of Continuous Bevacizumab Through Multiple Lines of Treatment for Recurrent Glioblastoma

Alba A. Brandes, Miguel Gil-Gil, Frank Saran, Antoine F. Carpentier, Anna K. Nowak, Warren Mason, Vittorina Zagonel, François Dubois, Gaetano Finocchiaro, George Fountzilas, Dana Michaela Cernea, Oliver Chinot, Rodica Anghel, Francois Ghiringhelli, Patrick Beauchesne, Giuseppe Lombardi, Enrico Franceschi, Martina Makrutzki, Chiedzo Mpofu, Hans-Joerg Urban, Josef Pichler

The Oncologist first published on September 28, 2018; doi:10.1634/theoncologist.2018-0290


Cosmetic Consequences of Breast-Conserving Treatment for Breast Cancer: Something Worth Talking About

Angelique Brands-Appeldoorn, Sabrina Maaskant-Braat, Karin Schenk, Rudi Roumen

The Oncologist first published on September 26, 2018; doi:10.1634/theoncologist.2017-0443


Results from a Monocentric Long-Term Analysis of 23 Patients with Ovarian Sertoli-Leydig Cell Tumors

Sebastien Gouy, Alexandra Arfi, Amandine Maulard, Patricia Pautier, Enrica Bentivegna, Alexandra Leary, Cyrus Chargari, Catherine Genestie, Philippe Morice

The Oncologist first published on September 10, 2018; doi:10.1634/theoncologist.2017-0632


“I need to know what makes somebody tick …”: Challenges and Strategies of Implementing Shared Decision-Making in Individualized Oncology

Joschka Haltaufderheide, Sebastian Wäscher, Bernhard Bertlich, Jochen Vollmann, Anke Reinacher-Schick, Jan Schildmann

The Oncologist first published on September 6, 2018; doi:10.1634/theoncologist.2017-0615


Regorafenib for Patients with Metastatic Colorectal Cancer Who Progressed After Standard Therapy: Results of the Large, Single-Arm, Open-Label Phase IIIb CONSIGN Study

Eric Van Cutsem, Erika Martinelli, Stefano Cascinu, Alberto Sobrero, Maria Banzi, Jean-François Seitz, Carlo Barone, Marc Ychou, Marc Peeters, Baruch Brenner, Ralf Dieter Hofheinz, Evaristo Maiello, Thierry André, Andrea Spallanzani, Rocio Garcia-Carbonero, Yull E. Arriaga, Udit Verma, Axel Grothey, Christian Kappeler, Ashok Miriyala, Joachim Kalmus, Alfredo Falcone, Alberto Zaniboni

The Oncologist first published on September 6, 2018; doi:10.1634/theoncologist.2018-0072


Expenditures on Oncology Drugs and Cancer Mortality-to-Incidence Ratio in Central and Eastern Europe

Eduard Vrdoljak, Gyorgy Bodoky, Jacek Jassem, Razvan Popescu, Robert Pirker, Tanja Čufer, Semir Bešlija, Alexandru Eniu, Vladimir Todorović, Katerina Kopečková, Galia Kurteva, Zorica Tomašević, Agim Sallaku, Snezhana Smichkoska, Žarko Bajić, Branimir Sikic

The Oncologist first published on September 4, 2018; doi:10.1634/theoncologist.2018-0093


Oral Ondansetron Offers Effective Antidiarrheal Activity for Carcinoid Syndrome Refractory to Somatostatin Analogs

Barbara Kiesewetter, Heying Duan, Wolfgang Lamm, Alexander Haug, Philipp Riss, Andreas Selberherr, Christian Scheuba, Markus Raderer

The Oncologist first published on on August 31, 2018; doi:10.1634/theoncologist.2018-0191


The Current and Evolving Landscape of First-Line Treatments for Advanced Renal Cell Carcinoma

Emiliano Calvo, Camillio Porta, Viktor Grünwald, Bernard Escudier

The Oncologist first published on August 29, 2018; doi:10.1634/theoncologist.2018-0267


Definitive Radiotherapy in Invasive Vaginal Carcinoma: A Systematic Review

Consuelo Buttigliero, Frances A. Shepherd, Fabrice Barlesi, Brian Schwartz, Sergey Orlov, Adolfo G. Favaretto, Armando Santoro, Vera Hirsh, Rodryg Ramlau, Adele R. Blackler, Joanna Roder, David Spigel, Silvia Novello, Wallace Akerley, Giorgio V. Scagliotti

The Oncologist first published on August 23, 2018; doi:10.1634/theoncologist.2017-0546


Retrospective Assessment of a Serum Proteomic Test in a Phase III Study Comparing Erlotinib plus Placebo with Erlotinib plus Tivantinib (MARQUEE) in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer

Consuelo Buttigliero, Frances A. Shepherd, Fabrice Barlesi, Brian Schwartz, Sergey Orlov, Adolfo G. Favaretto, Armando Santoro, Vera Hirsh, Rodryg Ramlau, Adele R. Blackler, Joanna Roder, David Spigel, Silvia Novello, Wallace Akerley, Giorgio V. Scagliotti

The Oncologist first published on August 23, 2018; doi:10.1634/theoncologist.2018-0089


Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib

César Serrano, Xavier García-del-Muro, Claudia Valverde, Ana Sebio, José Durán, Aránzazu Manzano, Isabel Pajares, Nadia Hindi, Stefania Landolfi, Laura Jiménez, Jordi Rubió-Casadevall, Anna Estival, Javier Lavernia, María José Safont, Carles Pericay, Roberto Díaz-Beveridge, Virginia Martínez-Marín, David Vicente-Baz, Ana Vivancos, Javier Hernández-Losa, Joaquín Arribas, Joan Carles

The Oncologist first published on August 20, 2018; doi:10.1634/theoncologist.2018-0032


Another Chapter of the Right Versus Left Story: Is Primary Tumor Location a Prognostic Feature in RAS Mutant Metastatic Colorectal Cancer?

Fotios Loupakis, Marta Schirripa, Rossana Intini, Francesca Bergamo, Roberta Bertorelle, Matteo Fassan, Vincenzo Dadduzio, Stefano Merigliano, Pierluigi Pilati, Emanuele Luca Damiano Urso, Umberto Cillo, Massimo Rugge, Sara Lonardi, Vittorina Zagonel

The Oncologist first published on August 17, 2018;doi:10.1634/theoncologist.2018-0180


Single-Agent Regorafenib in Metastatic Colorectal Cancer Patients with Any RAS or BRAF Mutation Previously Treated with FOLFOXIRI plus Bevacizumab (PREVIUM Trial)

Pilar García-Alfonso, Manuel Benavides, Esther Falcó, Andrés Muñoz, Auxiliadora Gómez, Javier Sastre, Fernando Rivera, Clara Montagut, Mercedes Salgado, Amelia López-Ladrón, Rafael López, Inmaculada Ruiz de Mena, Gema Durán, Enrique Aranda, on behalf of the Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD)

The Oncologist first published on August 17, 2018; doi:10.1634/theoncologist.2018-0316


Clinicopathological and Treatment-Associated Prognostic Factors in Patients with Breast Cancer Leptomeningeal Metastases in Relation to Tumor Biology

Gaia Griguolo, Stephane Pouderoux, Maria Vittoria Dieci, William Jacot, Céline Bourgier, Federica Miglietta, Nelly Firmin, Pierfranco Conte, Marie Viala, Valentina Guarneri, Amélie Darlix

The Oncologist first published on August 17, 2018; doi:10.1634/theoncologist.2018-0200


Prospective Assessment of Clinical Risk Factors and Biomarkers of Hypercoagulability for the Identification of Patients with Lung Adenocarcinoma at Risk for Cancer-Associated Thrombosis: The Observational ROADMAP-CAT Study

Konstantinos Syrigos, Dimitra Grapsa, Rabiatou Sangare, Ilias Evmorfiadis, Annette K. Larsen, Patrick Van Dreden, Paraskevi Boura, Andriani Charpidou, Elias Kotteas, Theodoros N. Sergentanis, Ismail Elalamy, Anna Falanga, Grigoris T. Gerotziafas

The Oncologist first published on August 13, 2018; doi:10.1634/theoncologist.2017-0530


Effectiveness of First-Line Bevacizumab in Metastatic Colorectal Cancer: The Observational Cohort Study GRETA

Matteo Franchi, Sandro Barni, Giovanna Tagliabue, Paolo Ricci, Walter Mazzucco, Rosario Tumino, Antonietta Caputo, Giovanni Corrao, on behalf of the GRETA working group

The Oncologist first published on August 10, 2018; doi:10.1634/theoncologist.2017-0314


NGR-hTNF and Doxorubicin as Second-Line Treatment of Patients with Small Cell Lung Cancerp

Vanesa Gregorc, Raffaele Cavina, Sivia Novello, Francesco Grossi, Chiara Lazzari, Enrica Capelletto, Carlo Genova, Giulia Salini, Antonio Lambiase, Armando Santoro

The Oncologist first published on August 3, 2018; doi:10.1634/theoncologist.2018-0292


Non-Small Cell Lung Cancer in Countries of Central and Southeastern Europe: Diagnostic Procedures and Treatment Reimbursement Surveyed by the Central European Cooperative Oncology Group

Ales Ryska, Rares Buiga, Albena Fakirova, Izidor Kern, Włodzimierz Olszewski, Lukas Plank, Sven Seiwerth, Erika Toth, Eri Zivka, Christiane Thallinger, Christoph Zielinski, Luka Brcic

The Oncologist first published on August 3, 2018; doi:10.1634/theoncologist.2018-0008


Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma

Shai Rosenberg, Francois Ducray, Agusti Alentorn, Caroline Dehais, Nabila Elarouci, Aurelie Kamoun, Yannick Marie, Marie-Laure Tanguy, Aurélien De Reynies, Karima Mokhtari, Dominique Figarella-Branger, Jean-Yves Delattre, Ahmed Idbaih, POLA Network

The Oncologist 2018 first published on July 17, 2018; doi:10.1634/theoncologist.2017-0495


Selection of Protein Kinase Inhibitors Based on Tumor Tissue Kinase Activity Profiles in Patients with Refractory Solid Malignancies: An Interventional Molecular Profiling Study

Mariette Labots, Johannes C. Van der Mijn, Henk Dekker, Rita Ruijter, Thang V. Pham, Hans J. Van der Vliet, Jacobus J.M. Van der Hoeven, Gerrit A. Meijer, Henk M.W. Verheul

The Oncologist 2018 first published on July 17, 2018; doi:10.1634/theoncologist.2018-0263


Training for Medical Oncologists on Shared Decision-Making About Palliative Chemotherapy: A Randomized Controlled Trial

Inge Henselmans, Hanneke W.M. van Laarhoven, Hanneke C.J.M. de Haes, Meltem Tokat, Ellen G. Engelhardt, Pomme E.A. van Maarschalkerweerd, Marleen Kunneman, Petronella B. Ottevanger, Serge E. Dohmen, Geert-Jan Creemers, Dirkje W. Sommeijer, Filip Y.F.L. de Vos, Ellen M.A. Smets

The Oncologist first published on June 29, 2018; doi:10.1634/theoncologist.2018-0090


Cognitive Changes After Adjuvant Treatment in Older Adults with Early-Stage Breast Cancer

Marie Lange, Natacha Heutte, Sabine Noal, Olivier Rigal, Jean-Emmanuel Kurtz, Christelle Lévy, Djelila Allouache, Chantal Rieux, Johan Lefel, Bénédicte Clarisse, Alexandra Leconte, Corinne Veyret, Philippe Barthélémy, Nadine Longato, Laure Tron, Hélène Castel, Francis Eustache, Bénédicte Giffard, Florence Joly

The Oncologist first published on June 22, 2018; doi:10.1634/theoncologist.2017-0570


Brain Metastases from Adult Sarcoma: Prognostic Factors and Impact of Treatment. A Retrospective Analysis from the French Sarcoma Group (GSF/GETO)

Loïc Chaigneau, Anna Patrikidou, Isabelle Ray-Coquard, Thibaud Valentin, Claude Linassier, Jacques Olivier Bay, Laurence Moureau Zabotto, Emmanuelle Bompas, Sophie Piperno-Neumann, Nicolas Penel, Thierry Alcindor, Maryline Laigre, Cecile Guillemet, Sebastien Salas, Anne Hugli, Julien Domont, Marie Pierre Sunyach, Axel Lecesne, Jean Yves Blay, Virginie Nerich, Nicolas Isambert

The Oncologist 2018 first published on June 22, 2018; doi:10.1634/theoncologist.2017-0136


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